Article
Anti-fibrogenic Potential of Mesenchymal Stromal Cells in Treating Fibrosis in Crohn's Disease.
Digestive diseases and sciences - 1 Jul 2018
Lian Lei, Huang Qunsheng, Zhang Longjuan, Qin Huabo, He Xiaosheng, He Xin, Ke Jia, Xie Minghao, Lan Ping
Abstract excerpt
BACKGROUND: Intestinal fibrosis is a major complication of CD and may result in stricture formation leading to intestinal obstruction. MSCs play multiple roles in active CD and fibrosis-associated diseases. AIMS: This study was designed to investigate the role of MSCs in CD-associated intestinal fibrosis. METHODS: Intestinal fibrosis was induced over 7 weeks of enema with increasing doses of TNBS and assessed by...
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