Article
Adaptive evolution in perinatal HIV-1.
Best practice & research. Clinical obstetrics & gynaecology - 1 Apr 2005
Pillay Thillagavathie, Phillips Rodney E
Abstract excerpt
The immune-viral dynamics of the transmission of HIV-1 from mother to child are poorly understood, despite 20 years of research. Here we review evidence that the maternal immune response against HIV-1 can select forms of the virus that evade immunity and when transmitted have negative consequences in the child. Moreover, recent studies indicate that when wild-type virus is transmitted, an early immune response in...
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