Adaptive evolution in perinatal HIV-1.

doi:10.1016/j.bpobgyn.2004.10.004

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Article

Adaptive evolution in perinatal HIV-1.

Best practice & research. Clinical obstetrics & gynaecology - 1 Apr 2005

Pillay Thillagavathie, Phillips Rodney E

Abstract excerpt

The immune-viral dynamics of the transmission of HIV-1 from mother to child are poorly understood, despite 20 years of research. Here we review evidence that the maternal immune response against HIV-1 can select forms of the virus that evade immunity and when transmitted have negative consequences in the child. Moreover, recent studies indicate that when wild-type virus is transmitted, an early immune response in...

Topics

Biological Evolution
Female
Genetic Variation
HIV Antibodies
HIV Infections
HIV-1
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Male
Pregnancy
Pregnancy Complications, Infectious
Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 15778111
DOI: 10.1016/j.bpobgyn.2004.10.004

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