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Article

Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection in fetuses.

Cell reports. Medicine - 20 Jul 2021

Marichannegowda Manukumar Honnayakanahalli, Mengual Michael, Kumar Amit, Giorgi Elena E, Tu Joshua J, Martinez David R, Romero-Severson Ethan O, Li Xiaojun, Feng Liping, Permar Sallie R, Gao Feng

Abstract excerpt

Study of evolution and selection pressure on HIV-1 in fetuses will lead to a better understanding of the role of immune responses in shaping virus evolution and vertical transmission. Detailed genetic analyses of HIV-1 env gene from 12 in utero transmission pairs show that most infections (67%) occur within 2 months of childbirth. In addition, the env sequences from long-term-infected fetuses are highly divergent...

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Identifiers

PMID: 34337555
DOI: 10.1016/j.xcrm.2021.100315
PMCID: PMC8324465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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