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Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children

12 Apr 2021

Abstract excerpt

HIV-1 integrates its genome into the DNA of host cells. Consequently, HIV-1 genomes are copied with the host cell DNA during cellular division. Pediatric immune systems differ significantly from adults, consisting primarily of naive T cells, which have low expression of the HIV-1 coreceptor CCR5. This difference may result in variances in the number or size of infected cell clones that persist in children on ART....

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PMID: 33832973
DOI: 10.1128/mbio.00568-21

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