Article
HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2005
Feeney Margaret E, Tang Yanhua, Pfafferott Katja, Roosevelt Kathleen A, Draenert Rika, Trocha Alicja, Yu Xu G, Verrill Cori, Allen Todd, Moore Corey, Mallal Simon, Burchett Sandra, McIntosh Kenneth, Pelton Stephen I, St John M Anne, Hazra Rohan, Klenerman Paul, Altfeld Marcus, Walker Bruce D, Goulder Philip J R
Abstract excerpt
Mutational escape from the CTL response represents a major driving force for viral diversification in HIV-1-infected adults, but escape during infancy has not been described previously. We studied the immune response of perinatally infected children to an epitope (B57-TW10) that is targeted early during acute HIV-1 infection in adults expressing HLA-B57 and rapidly mutates under this selection pressure. Viral...
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