Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants.

Journal of virology - 23 Jul 2024

Nazziwa Jamirah, Andrews Sophie M, Hou Mimi M, Bruhn Christian A W, Garcia-Knight Miguel A, Slyker Jennifer, Hill Sarah, Lohman Payne Barbara, Moringas Dorothy, Lemey Philippe, John-Stewart Grace, Rowland-Jones Sarah L, Esbjörnsson Joakim

Abstract excerpt

Escape from cytotoxic T lymphocyte (CTL) responses toward HIV-1 Gag and Nef has been associated with reduced control of HIV-1 replication in adults. However, less is known about CTL-driven immune selection in infants as longitudinal studies of infants are limited. Here, 1,210 gag and 1,264 nef sequences longitudinally collected within 15 months after birth from 14 HIV-1 perinatally infected infants and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to gag Gene Products, Human Immunodeficiency Virus
Share to HIV-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to Immune Evasion

Share to Infectious Disease Transmission, Vertical

Share to Longitudinal Studies

Share to nef Gene Products, Human Immunodeficiency Virus

Share to T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 38814066
DOI: 10.1128/jvi.00072-24
PMCID: PMC11265422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants.PMID 38814066Read ↗

HIV-1-specific CD8+ T cell responses and viral evolution in women and infants.Semantic proximity Read ↗

Sequence evolution of HIV-1 following mother-to-child transmission.Semantic proximity Read ↗

Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Adaptive evolution in perinatal HIV-1.Semantic proximity Read ↗

Evolution of human immunodeficiency virus type 1 in perinatally infected infants with rapid and slow progression to diseaseSemantic proximity Read ↗

Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the ariel project for the prevention of transmission of HIV from mother to infant.Semantic proximity Read ↗

Restricted genetic diversity of HIV-1 subtype C envelope glycoprotein from perinatally infected Zambian infants.Semantic proximity Read ↗

Viral sequence analysis from HIV-infected mothers and infants: molecular evolution, diversity, and risk factors for mother-to-child transmission.Semantic proximity Read ↗

HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.Semantic proximity Read ↗

Genotypic and functional properties of early infant HIV-1 envelopesSemantic proximity Read ↗

Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.Semantic proximity Read ↗

Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.