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Article

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.

American journal of human genetics - 1 May 2005

Vella Adrian, Cooper Jason D, Lowe Christopher E, Walker Neil, Nutland Sarah, Widmer Barry, Jones Richard, Ring Susan M, McArdle Wendy, Pembrey Marcus E, Strachan David P, Dunger David B, Twells Rebecca C J, Clayton David G, Todd John A

Abstract excerpt

As part of an ongoing search for genes associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (CD25), which encodes a subunit (IL-2R alpha) of the high-affinity interleukin-2 (IL-2) receptor complex. We employed a tag single-nucleotide polymorphism (tag SNP) approach in large T1D sample collections consisting of 7,457 cases and controls and 725 multiplex...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Interleukin-2 Receptor alpha Subunit

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 15776395
DOI: 10.1086/429843
PMCID: PMC1199367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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