Article
IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).
PloS one - 1 Jan 2009
Alcina Antonio, Fedetz María, Ndagire Dorothy, Fernández Oscar, Leyva Laura, Guerrero Miguel, Abad-Grau María M, Arnal Carmen, Delgado Concepción, Lucas Miguel, Izquierdo Guillermo, Matesanz Fuencisla
Abstract excerpt
BACKGROUND: IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity. METHODS AND RESULTS: Here we perform a replication and fine mapping of the IL2RA gene region analyzing 3 SNPs previously associated with multiple sclerosis (MS) and 5 SNPs associated with type 1 diabetes (T1D) in a collection of 798 MS patients and...
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