Article
Toward further mapping of the association between the IL2RA locus and type 1 diabetes.
Diabetes - 1 Apr 2007
Qu Hui-Qi, Montpetit Alexander, Ge Bing, Hudson Thomas J, Polychronakos Constantin
Abstract excerpt
A novel type 1 diabetes locus was mapped to the interleukin-2 receptor alpha gene (IL2RA) on chromosome 10p15.1, encoding an important modulator of immunity. The aim of the current study was to confirm the association of IL2RA with type 1 diabetes and to attempt further mapping of the genetic effect with a new set of 12 single nucleotide polymorphisms (SNPs). We genotyped 949 nuclear family trios with one type 1...
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