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Article

Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.

Arthritis and rheumatism - 1 Jan 2009

Hinks Anne, Ke Xiayi, Barton Anne, Eyre Steve, Bowes John, Worthington Jane, Thompson Susan D, Langefeld Carl D, Glass David N, Thomson Wendy

Abstract excerpt

OBJECTIVE: IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide polymorphisms (SNPs) within this gene with type 1 diabetes mellitus (DM), Graves' disease, rheumatoid arthritis (RA), and multiple sclerosis (MS). The aim of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19116909
DOI: 10.1002/art.24187
PMCID: PMC2963023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.PMID 19116909Read ↗

CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis.Semantic proximity Read ↗

Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap.Semantic proximity Read ↗

Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.Semantic proximity Read ↗

IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).Semantic proximity Read ↗

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The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice.Semantic proximity Read ↗

Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the Polish population.Semantic proximity Read ↗

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.Semantic proximity Read ↗

A variant of the Il2ra / Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor.Semantic proximity Read ↗

Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis.Semantic proximity Read ↗

A rare <i>IL2RA</i> haplotype identifies SNP rs61839660 as causal for autoimmunitySemantic proximity Read ↗

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