Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Nature genetics - 1 Sept 2007

Lowe Christopher E, Cooper Jason D, Brusko Todd, Walker Neil M, Smyth Deborah J, Bailey Rebecca, Bourget Kirsi, Plagnol Vincent, Field Sarah, Atkinson Mark, Clayton David G, Wicker Linda S, Todd John A

Abstract excerpt

Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the causal variant(s) requires comprehensive resequencing, extensive genotyping and statistical analyses in large sample sets leading to targeted functional studies. Here, we have localized the type 1 diabetes (T1D) association in the interleukin 2 receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Family Health

Share to Haplotypes

Share to Interleukin-2 Receptor alpha Subunit

Share to Linkage Disequilibrium

Share to Logistic Models

Share to Odds Ratio

Source

Identifiers

PMID: 17676041
DOI: 10.1038/ng2102

Genes

RBM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.PMID 17676041Read ↗

Toward further mapping of the association between the IL2RA locus and type 1 diabetes.Semantic proximity Read ↗

The type I diabetes association of the IL2RA locus.Semantic proximity Read ↗

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.Semantic proximity Read ↗

IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).Semantic proximity Read ↗

Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies.Semantic proximity Read ↗

A cis-acting regulatory variant in the IL2RA locus.Semantic proximity Read ↗

A rare <i>IL2RA</i> haplotype identifies SNP rs61839660 as causal for autoimmunitySemantic proximity Read ↗

Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients.Semantic proximity Read ↗

Genetic association of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians.Semantic proximity Read ↗

Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits.Semantic proximity Read ↗

[Haplotypes in the IL2RA region associated with diabetes and expression of the IL2RA protein on lymphocytes populations].Semantic proximity Read ↗

Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the Polish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.