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Article

Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/- mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2005

Resta-Lenert Silvia, Smitham Jane, Barrett Kim E

Abstract excerpt

P-glycoprotein, the product of the multidrug resistance protein 1 (MDR1) gene, is a xenobiotic transporter that may contribute to the physiology of the intestinal barrier. Twenty-five percent of mdr1a-deficient (mdr1a(-/-)) mice spontaneously develop colitis at variable ages when maintained under specific pathogen-free conditions. We hypothesized that this disease would result from epithelial dysfunction and that...

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Share to Antigens, Bacterial
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15774938
DOI: 10.1152/ajpgi.00395.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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