Article
MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation.
Mucosal immunology - 1 Jan 2018
Ho G-T, Aird R E, Liu B, Boyapati R K, Kennedy N A, Dorward D A, Noble C L, Shimizu T, Carter R N, Chew E T S, Morton N M, Rossi A G, Sartor R B, Iredale J P, Satsangi J
Abstract excerpt
The multidrug resistance-1 (MDR1) gene encodes an ATP-dependent efflux transporter that is highly expressed in the colon. In mice, loss of MDR1 function results in colitis with similarities to human inflammatory bowel diseases (IBD). Here, we show that MDR1 has an unexpected protective role for the mitochondria where MDR1 deficiency results in mitochondrial dysfunction with increased mitochondrial reactive oxygen...
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