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Article

Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.

American journal of physiology. Gastrointestinal and liver physiology - 1 Feb 2011

Banerjee Sanjita, Jin Ge, Bradley S Gaylen, Matters Gail L, Gailey Ryan D, Crisman Jacqueline M, Bond Judith S

Abstract excerpt

MEP1A, which encodes the α subunit of meprin metalloproteinases, is a susceptibility gene for inflammatory bowel disease (IBD), and decreased intestinal meprin-α expression is associated with enhanced IBD in humans. Mice lacking meprin α (α knockout, αKO) have more severe colitis induced by dextran sulfate sodium (DSS) than wild-type (WT) mice, indicating an anti-inflammatory role for meprin A. Previous studies...

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Identifiers

PMID: 21071511
DOI: 10.1152/ajpgi.00504.2009
PMCID: PMC3043644

Genes

MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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