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Article

Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2013

Ey Birgit, Eyking Annette, Klepak Magdalena, Salzman Nita H, Göthert Joachim R, Rünzi Michael, Schmid Kurt W, Gerken Guido, Podolsky Daniel K, Cario Elke

Abstract excerpt

Variants of the multidrug resistance gene (MDR1/ABCB1) have been associated with increased susceptibility to severe ulcerative colitis (UC). In this study, we investigated the role of TLR/IL-1R signaling pathways including the common adaptor MyD88 in the pathogenesis of chronic colonic inflammation in MDR1A deficiency. Double- or triple-null mice lacking TLR2, MD-2, MyD88, and MDR1A were generated in the FVB/N...

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Source

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Identifiers

PMID: 23636052
DOI: 10.4049/jimmunol.1201592
PMCID: PMC3659955

Genes

TLR2
ABCB1
TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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