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Article

Impact of disrupting adenosine A₃ receptors (A₃⁻/⁻ AR) on colonic motility or progression of colitis in the mouse.

Inflammatory bowel diseases - 1 Aug 2011

Ren Tianhua, Grants Iveta, Alhaj Mazin, McKiernan Matt, Jacobson Marlene, Hassanain Hamdy H, Frankel Wendy, Wunderlich Jacqueline, Christofi Fievos L

Abstract excerpt

BACKGROUND: Pharmacological studies suggest that adenosine A₃AR influences motility and colitis. Functional A₃⁻/⁻AR knockout mice were used to prove whether A₃AR activation is involved in modulating either motility or colitis. METHODS: A₃AR was probed by polymerase chain reaction (PCR) genotyping, Western blot, and immunochemistry. Motility was assessed in vivo by artificial bead-expulsion, stool-frequency, and...

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PMID: 21744424
DOI: 10.1002/ibd.21553
PMCID: PMC3116114

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MPO

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