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Article

Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammation

30 Apr 2025

Abstract excerpt

Disruption of the circadian clock is associated with the development of inflammatory bowel disease (IBD), but the underlying mechanisms remain unclear. Here, we observe that mice in the early active phase (Zeitgeber time 12, ZT12) of the circadian clock are more tolerant to dextran sodium sulfate (DSS)-induced colitis, compared to those in the early resting phase (ZT0). The expression of the circadian gene Bmal1...

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PMID: 40307620
DOI: 10.1038/s44319-025-00464-y

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