Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Canonical and alternate functions of the microRNA biogenesis machinery.

Genes & development - 1 Sept 2010

Chong Mark M W, Zhang Guoan, Cheloufi Sihem, Neubert Thomas A, Hannon Gregory J, Littman Dan R

Abstract excerpt

The canonical microRNA (miRNA) biogenesis pathway requires two RNaseIII enzymes: Drosha and Dicer. To understand their functions in mammals in vivo, we engineered mice with germline or tissue-specific inactivation of the genes encoding these two proteins. Changes in proteomic and transcriptional profiles that were shared in Dicer- and Drosha-deficient mice confirmed the requirement for both enzymes in canonical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to Endoribonucleases
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Inverted Repeat Sequences

Share to MicroRNAs

Share to Ribonuclease III

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 20713509
DOI: 10.1101/gad.1953310
PMCID: PMC2932976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Canonical and alternate functions of the microRNA biogenesis machinery.PMID 20713509Read ↗

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs.Semantic proximity Read ↗

Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants.Semantic proximity Read ↗

A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs.Semantic proximity Read ↗

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.Semantic proximity Read ↗

Processing of primary microRNAs by the Microprocessor complex.Semantic proximity Read ↗

A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline enriched miRNA familySemantic proximity Read ↗

A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.Semantic proximity Read ↗

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.Semantic proximity Read ↗

The RNase III Enzyme DROSHA Is Essential for MicroRNA Production and SpermatogenesisSemantic proximity Read ↗

A comprehensive analysis of precursor microRNA cleavage by human Dicer.Semantic proximity Read ↗

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.Semantic proximity Read ↗

MicroRNA Expression: Protein Participants in MicroRNA Regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.