Article
Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2010
Huang Zhan-Peng, Chen Jian-Fu, Regan Jenna N, Maguire Colin T, Tang Ru-Hang, Dong Xiu Rong, Majesky Mark W, Wang Da-Zhi
Abstract excerpt
OBJECTIVE: Congenital heart defects represent the most common human birth defects. Even though the genetic cause of these syndromes has been linked to candidate genes, the underlying molecular mechanisms are still largely unknown. Disturbance of neural crest cell (NCC) migration into the derivatives of the pharyngeal arches and pouches can account for many of the developmental defects. The goal of this study was...
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