Article
Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2009
Kawase-Koga Yoko, Otaegi Gaizka, Sun Tao
Abstract excerpt
MicroRNAs, processed by the RNAase III enzyme Dicer, are approximately 22 nucleotide endogenous noncoding small RNAs. The function of Dicer in the mouse central nervous system (CNS) development is not well understood. Here, we show that specifically deleting Dicer expression in the CNS and in the cerebral cortex using two Cre lines results in reduced progenitor numbers, abnormal neuronal differentiation, and...
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