Article
Blocking miRNA Biogenesis in Adult Forebrain Neurons Enhances Seizure Susceptibility, Fear Memory, and Food Intake by Increasing Neuronal Responsiveness.
Cerebral cortex (New York, N.Y. : 1991) - 1 Apr 2016
Fiorenza Anna, Lopez-Atalaya Jose P, Rovira Victor, Scandaglia Marilyn, Geijo-Barrientos Emilio, Barco Angel
Abstract excerpt
The RNase Dicer is essential for the maturation of most microRNAs, a molecular system that plays an essential role in fine-tuning gene expression. To gain molecular insight into the role of Dicer and the microRNA system in brain function, we conducted 2 complementary RNA-seq screens in the hippocampus of inducible forebrain-restricted Dicer1 mutants aimed at identifying the microRNAs primarily affected by Dicer...
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