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Article

[Detection of single base polymorphism in p53 gene by ligase detection reaction and rolling circle amplification on microarrays].

Molekuliarnaia biologiia - 1 Jan 2000

Kashkin K N, Strizhkov B N, Griadunov D A, Surzhikov S A, Grechishnikova I V, Kreĭndlin E Ia, Chupeeva V V, Evseev K B, Turygin A Iu, Mirzabekov A D

Abstract excerpt

We combined three modern technologies of single base polymorphism detection in human genome: ligase detection reaction, rolling circle amplification and IMAGE hydro-gel microarrays. Polymorphism in target DNA was tested by selective ligation on microarray. Product of the ligase reaction was determined in microarray gel pads by rolling circle amplification. Two different methods were compared. In first, selective...

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PMID: 15773545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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