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Article

Ligase chain reaction coupled with rolling circle amplification for high sensitivity detection of single nucleotide polymorphisms.

The Analyst - 21 May 2013

Cheng Yongqiang, Zhao Jingjing, Jia Hailian, Yuan Zheng, Li Zhengping

Abstract excerpt

We present a highly sensitive and homogeneous assay for the detection of single nucleotide polymorphisms (SNPs) by ligase chain reaction (LCR) coupled with rolling circle amplification (RCA). The LCR probes include one pair of probes and a padlock probe (PLP). In the LCR, one pair of probes composed of X and Y, perfectly hybridize with the upper strand of the target DNA after thermal denaturation. They are then...

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PMID: 23535938
DOI: 10.1039/c3an36920j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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