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Article

Enhanced discrimination of single nucleotide polymorphisms using 3' nucleotide differences in ligase detection reaction probes.

Molecular and cellular probes - 1 Dec 2010

Asari Masaru, Omura Tomohiro, Maseda Chikatoshi, Shiono Hiroshi, Tasaki Yoshikazu, Matsubara Kazuo, Shimizu Keiko

Abstract excerpt

The ligase detection reaction (LDR) is a highly specific genotyping method for single nucleotide variations. Although LDR typically discriminates single nucleotide polymorphism (SNP) alleles at the 3' end of so-called LDR discriminating probes, we designed probes in which the position of nucleotide differences for discrimination was shifted to the second and third nucleotides from the 3' end. Using the...

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PMID: 20797430
DOI: 10.1016/j.mcp.2010.08.005

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ABO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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