Article
Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.
Human mutation - 1 Jan 2004
Fukushima-Uesaka Hiromi, Saito Yoshiro, Watanabe Hidemi, Shiseki Kisho, Saeki Mayumi, Nakamura Takahiro, Kurose Kouichi, Sai Kimie, Komamura Kazuo, Ueno Kazuyuki, Kamakura Shiro, Kitakaze Masafumi, Hanai Sotaro, Nakajima Toshiharu, Matsumoto Kenji, Saito Hirohisa, Goto Yu-ichi, Kimura Hideo, Katoh Masaaki, Sugai Kenji, Minami Narihiro, Shirao Kuniaki, Tamura Tomohide, Yamamoto Noboru, Minami Hironobu, Ohtsu Atsushi, Yoshida Teruhiko, Saijo Nagahiro, Kitamura Yutaka, Kamatani Naoyuki, Ozawa Shogo, Sawada Jun-ichi
Abstract excerpt
In order to identify single nucleotide polymorphisms (SNPs) and haplotype frequencies of CYP3A4 in a Japanese population, the distal enhancer and proximal promoter regions, all exons, and the surrounding introns were sequenced from genomic DNA of 416 Japanese subjects. We found 24 SNPs, including 17 novel ones: two in the distal enhancer, four in the proximal promoter, one in the 5'-untranslated region (UTR),...
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