Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability

10 Oct 2003

Abstract excerpt

PURPOSE: DNA methylation is an important biologic event in colorectal cancer and in some cases is associated with the development of microsatellite instability (MSI). In this study, we sought to determine the prognostic significance of DNA methylation, both in univariate analysis and in concert with other clinicopathologic factors known to influence outcome. PATIENTS AND METHODS: Fresh tissue (625 cancers) was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Cancer Treatments and Studies
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14551292
DOI: 10.1200/jco.2003.03.123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite InstabilityPMID 14551292Read ↗

Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications.Semantic proximity Read ↗

Reduced Likelihood of Metastases in Patients with Microsatellite-Unstable Colorectal CancerSemantic proximity Read ↗

The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile.Semantic proximity Read ↗

Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation.Semantic proximity Read ↗

Interaction between Microsatellite Instability (MSI) and Tumor DNA Methylation in the Pathogenesis of Colorectal CarcinomaSemantic proximity Read ↗

Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African AmericansSemantic proximity Read ↗

Development of sporadic microsatellite instability in colorectal tumors involves hypermethylation at methylated-in-tumor loci in adenoma.Semantic proximity Read ↗

RNA methylation-related genes INHBB and SOWAHA are associated with MSI status in colorectal cancer patients and may serve as prognostic markers for predicting immunotherapy efficacySemantic proximity Read ↗

Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer.Semantic proximity Read ↗

Clinical Relevance of Microsatellite Instability in Colorectal CancerSemantic proximity Read ↗

Distal Colorectal Cancers with Microsatellite Instability (MSI) Display Distinct Gene Expression Profiles that Are Different from Proximal MSI CancersSemantic proximity Read ↗

The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.