Article
Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection.
Journal of leukocyte biology - 1 Jun 2005
Gonzalez-Juarrero Mercedes, Hattle Jessica M, Izzo Angelo, Junqueira-Kipnis Ana Paula, Shim Tae S, Trapnell Bruce C, Cooper Andrea M, Orme Ian M
Abstract excerpt
Mice lacking expression of granulocyte macrophage-colony stimulating factor (GM-CSF KO) are unable to contain Mycobacterium tuberculosis (M. tuberculosis) growth and succumb to infection by 35 days following pulmonary challenge. GM-CSF KO mice do not express normal levels of the inflammatory cyto...
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