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Article

Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2000

Paine R, Preston A M, Wilcoxen S, Jin H, Siu B B, Morris S B, Reed J A, Ross G, Whitsett J A, Beck J M

Abstract excerpt

Innate immunity plays an important role in pulmonary host defense against Pneumocystis carinii, an important pathogen in individuals with impaired cell-mediated immunity. We investigated the role of GM-CSF in host defense in a model of P. carinii pneumonia induced by intratracheal inoculation of CD4-depleted mice. Lung GM-CSF levels increased progressively during the infection and were significantly greater than...

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Source

Identifiers

PMID: 10679099
DOI: 10.4049/jimmunol.164.5.2602

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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