Article
Mice unresponsive to GM-CSF are unexpectedly resistant to cutaneous Leishmania major infection.
Microbes and infection - 1 Aug 2000
Scott C L, Roe L, Curtis J, Baldwin T, Robb L, Begley C G, Handman E
Abstract excerpt
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to play a protective role in leishmanial infection. Mice with a null mutation in the gene for the beta common (beta c) chain of the receptors for GM-CSF, interleukin(IL)-3 and IL-5 (beta c-null mice) display normal steady state hemopoiesis and develop lung disease similar to the human condition, alveolar proteinosis, due to a lack of...
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