Article
Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin in IL-12-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1998
Wakeham J, Wang J, Magram J, Croitoru K, Harkness R, Dunn P, Zganiacz A, Xing Z
Abstract excerpt
Understanding of key cytokines and the nature of protective immune responses in pulmonary mycobacterial diseases remains a task of paramount importance. In this study, both wild-type (wt) and IL-12-deficient (IL-12(-/-)) mice were infected by airways inoculation of live Mycobacterium bovis bacill...
Topics
- Animals
- Cytokines
- Enzyme-Linked Immunosorbent Assay
- Granulocyte-Macrophage Colony-Stimulating Factor
- Interferon-gamma
- Interleukin-12
- Interleukin-4
- Lung
- Mice
- Mice, Inbred C57BL
- Mycobacterium bovis
- Phenotype
- Th1 Cells
- Tuberculosis, Pulmonary