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Article

Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2008

Higgins David M, Sanchez-Campillo Joaquin, Rosas-Taraco Adrian G, Higgins Jonathan R, Lee Eric J, Orme Ian M, Gonzalez-Juarrero Mercedes

Abstract excerpt

Members of the CSF cytokine family play important roles in macrophage recruitment and activation. However, the role of M-CSF in pulmonary infection with Mycobacterium tuberculosis is not clear. In this study, we show the lungs of mice infected with M. tuberculosis displayed a progressive decrease in M-CSF in contrast to increasing levels of GM-CSF. Restoring pulmonary M-CSF levels during infection resulted in a...

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Source

Identifiers

PMID: 18354213
DOI: 10.4049/jimmunol.180.7.4892

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis.PMID 18354213Read ↗

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