Article
Interferon regulatory factor 8-deficiency determines massive neutrophil recruitment but T cell defect in fast growing granulomas during tuberculosis.
PloS one - 1 Jan 2013
Rocca Stefano, Schiavoni Giovanna, Sali Michela, Anfossi Antonio Giovanni, Abalsamo Laura, Palucci Ivana, Mattei Fabrizio, Sanchez Massimo, Giagu Anna, Antuofermo Elisabetta, Fadda Giovanni, Belardelli Filippo, Delogu Giovanni, Gabriele Lucia
Abstract excerpt
Following Mycobacterium tuberculosis (Mtb) infection, immune cell recruitment in lungs is pivotal in establishing protective immunity through granuloma formation and neogenesis of lymphoid structures (LS). Interferon regulatory factor-8 (IRF-8) plays an important role in host defense against Mtb, although the mechanisms driving anti-mycobacterial immunity remain unclear. In this study, IRF-8 deficient mice...
Topics
- Animals
- Genetic Association Studies
- Genetic Predisposition to Disease
- Granuloma, Respiratory Tract
- Humans
- Interferon Regulatory Factors
- Lung
- Lymphoid Tissue
- Mice