Article
Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.
PloS one - 1 Jan 2018
Dehghanizadeh Somaye, Khoddami Vahid, Mosbruger Timothy L, Hammoud Sue S, Edes Kornelia, Berry Therese S, Done Michelle, Samowitz Wade S, DiSario James A, Luba Daniel G, Burt Randall W, Jones David A
Abstract excerpt
BACKGROUND: Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the polyps. The underlying genetic and epigenetic basis for the emergence of SSPs is largely unknown with existing genetic studies confined to a limited...
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