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Article

Increased cancer predisposition in family members of colorectal cancer patients harboring the p.V600E BRAF mutation: a population-based study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2010

Wish Tyler A, Hyde Angela J, Parfrey Patrick S, Green Jane S, Younghusband H Banfield, Simms Michelle I, Fontaine Dan G, Dicks Elizabeth L, Stuckless Susan N, Gallinger Steven, McLaughlin John R, Woods Michael O, Green Roger C

Abstract excerpt

BACKGROUND: The serrated pathway represents a distinct molecular pathway of colorectal carcinogenesis and is associated with the p.V600E BRAF mutation. The objective of this study is to characterize the cancer family history and clinicopathologic features of colorectal cancer (CRC) patients accor...

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Identifiers

PMID: 20570909
DOI: 10.1158/1055-9965.EPI-10-0055

Genes

BRAF
APC
IMPACT
MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20570909-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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