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Article

Adaptation of influenza B virus by serial passage in human airway epithelial cells.

Virology - 1 Oct 2020

Ilyushina Natalia A, Lee Nicolette, Lugovtsev Vladimir Y, Kan Anastasia, Bovin Nicolai V, Donnelly Raymond P

Abstract excerpt

Influenza B viruses cause seasonal epidemics and are a considerable burden to public health. To understand their adaptation capability, we examined the genetic changes that occurred following 15 serial passages of two influenza B viruses, B/Brisbane/60/2008 and B/Victoria/504/2000, in human epithelial cells. Thirteen distinct amino acid mutations were found in the PB1, PA, hemagglutinin (HA), neuraminidase (NA),...

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Identifiers

PMID: 32853848
DOI: 10.1016/j.virol.2020.08.004

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