Article
Analysis of Single Nucleotide Variants (SNVs) Induced by Passages of Equine Influenza Virus H3N8 in Embryonated Chicken Eggs.
Viruses - 5 Aug 2021
Rozek Wojciech, Kwasnik Malgorzata, Socha Wojciech, Sztromwasser Pawel, Rola Jerzy
Abstract excerpt
Vaccination is an effective method for the prevention of influenza virus infection. Many manufacturers use embryonated chicken eggs (ECE) for the propagation of vaccine strains. However, the adaptation of viral strains during subsequent passages can lead to additional virus evolution and lower effectiveness of the resulting vaccines. In our study, we analyzed the distribution of single nucleotide variants (SNVs)...
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