Article
p53 mutation profile of squamous cell carcinomas of the esophagus in Kashmir (India): a high-incidence area.
International journal of cancer - 10 Aug 2005
Mir Mohammad Muzaffar, Dar Nazir Ahmad, Gochhait Sailesh, Zargar Showkat Ali, Ahangar Abdul Gani, Bamezai R N K
Abstract excerpt
Esophageal squamous cell carcinoma (ESCC) has been reported to show geographical variation in its incidence, even within areas of ethnic homogeneity. Kashmir valley, in north of India, has been described as a high-risk area for ESCC. Here, we make a preliminary attempt to study mutations in exons 5-8 (the DNA binding domain) of the tumor suppressor gene, p53, in 55 ESCC patients from Kashmir. Polymerase chain...
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