Article
p53 gene mutation and human papillomavirus (HPV) infection in esophageal carcinoma from three different endemic geographic regions of India.
Cancer letters - 31 Jan 2005
Katiyar Sanjay, Hedau Suresh, Jain Neeraj, Kar Premashish, Khuroo Mohhamad S, Mohanta J, Kumar S, Gopalkrishna Varanasi, Kumar Nirmal, Das Bhudev C
Abstract excerpt
Infection of high-risk human papillomaviruses (HPVs), particularly the HPV types 16 and 18 and mutation or aberrant expression of the p53 tumour suppressor gene, has strongly been implicated in human esophageal carcinoma, which shows a great variation in geographic distribution. Neither the reason(s) for such a variation nor the etiopathogenesis of the disease is clearly understood. The present study has been...
Topics
- Adult
- Aged
- Alcohol Drinking
- Carcinoma
- Cultural Characteristics
- DNA Mutational Analysis
- Diet
- Esophageal Neoplasms
- Female
- Genes, p53
- Genetic Predisposition to Disease
- Geography
- Humans
