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Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalities.

Genes, chromosomes & cancer - 1 Aug 2008

Haruta Masayuki, Arai Yasuhito, Sugawara Waka, Watanabe Naoki, Honda Shohei, Ohshima Junjiro, Soejima Hidenobu, Nakadate Hisaya, Okita Hajime, Hata Jun-ichi, Fukuzawa Masahiro, Kaneko Yasuhiko

Abstract excerpt

The WT1 gene essential for the embryonic kidney development is mutated in 15-25% of Wilms tumors (WTs). To clarify whether genetic subtypes of WT1 abnormalities are correlated with IGF2 or CTNNB1 alterations or clinicopathological characteristics, we performed comprehensive WT1, IGF2, and CTNNB1 analyses of 36 WTs with WT1 abnormalities using single nucleotide polymorphism arrays, and methylation analysis of the...

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Identifiers

PMID: 18464243
DOI: 10.1002/gcc.20572

Genes

IGF2
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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