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Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors

24 Feb 2016

Abstract excerpt

BACKGROUND: Wilms tumor (WT) has a not completely elucidated pathogenesis. DNA copy number alterations (CNAs) are common in cancer, and often define key pathogenic events. The aim of this work was to investigate CNAs in order to disclose new candidate genes for Wilms tumorigenesis. RESULTS: Array-CGH of 50 primary WTs without pre-chemotherapy revealed a few recurrent CNAs not previously reported, such as 7q and...

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PMID: 26913079
DOI: 10.1186/s13039-016-0227-y

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