Article
Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis.
Molecular pharmacology - 1 Jun 2005
Lagane Bernard, Ballet Sébastien, Planchenault Thierry, Balabanian Karl, Le Poul Emmanuel, Blanpain Cédric, Percherancier Yann, Staropoli Isabelle, Vassart Gilbert, Oppermann Martin, Parmentier Marc, Bachelerie Françoise
Abstract excerpt
CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor that governs migration of leukocytes and serves as a coreceptor for the R5 tropic strains of human immunodeficiency virus (HIV). CCR5-mediated signaling in response to CC chemokines relies on G protein activation. Desensitization, which rapidly turns off G protein-dependent signaling, involves phosphorylation of CCR5 that promotes interaction of the...
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