Article
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5.
Journal of virology - 1 Feb 1998
Farzan M, Choe H, Vaca L, Martin K, Sun Y, Desjardins E, Ruffing N, Wu L, Wyatt R, Gerard N, Gerard C, Sodroski J
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) requires the presence of specific chemokine receptors in addition to CD4 to enter target cells. The chemokine receptor CCR5 is used by the macrophage-tropic strains of HIV-1 that predominate during the asymptomatic stages of infection. Here we identify...
Topics
- Animals
- Binding Sites
- Cell Line
- Dogs
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Mutation
- Receptors, CCR5
- Tyrosine
- Virus Replication