Article
Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor.
Traffic (Copenhagen, Denmark) - 1 Dec 2002
Whistler Jennifer L, Gerber Basil O, Meng Elaine C, Baranski Thomas J, von Zastrow Mark, Bourne Henry R
Abstract excerpt
Serpentine receptors relay hormonal or sensory stimuli to heterotrimeric guanine nucleotide-binding proteins (G proteins). In most G protein-coupled receptors (GPCRs), binding of the agonist ligand elicits both stimulation of the G protein and endocytosis of the receptor. We have begun to address whether these responses reflect the same sets of conformational changes in the receptor using constitutively active...
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