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Article

The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function.

Frontiers in immunology - 1 Jan 2018

Lu Mei-Yi, Lu Syuan-Shao, Chang Shiann-Luen, Liao Fang

Abstract excerpt

CCR6 is a G protein-coupled receptor (GPCR) that recognizes a single chemokine ligand, CCL20 and is primarily expressed by leukocytes. Upon ligand binding, CCR6 activates Gαi heterotrimeric G proteins to induce various potential cellular outcomes through context-specific cell signaling. It is well known that differential phosphorylation of Ser and Thr residues in the C-terminal domains or intracellular loops of...

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Identifiers

PMID: 29552015
DOI: 10.3389/fimmu.2018.00415
PMCID: PMC5840145

Genes

CCR6
CCL20

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