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Article

Evidence for Nonautonomous Effect of p53 Tumor Suppressor in Carcinogenesis

1 Mar 2005

Abstract excerpt

Prostate, breast, and probably other epithelial tumors harbor inactivating mutations in the p53 tumor suppressor gene in the stromal cells, implying the nonautonomous action of p53 in carcinogenesis. We have tested this hypothesis by evaluating the tumorigenicity of MCF7 human breast cancer cells in severe combined immunodeficient mice that differ in their p53 status. Our results showed that, indeed, p53 ablation...

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PMID: 15753354
DOI: 10.1158/0008-5472.can-04-3791

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Evidence for Nonautonomous Effect of p53 Tumor Suppressor in CarcinogenesisPMID 15753354Read ↗

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