Article
Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage.
Cancer research - 15 May 2007
Wijnhoven Susan W P, Speksnijder Ewoud N, Liu Xiaoling, Zwart Edwin, vanOostrom Conny Th M, Beems Rudolf B, Hoogervorst Esther M, Schaap Mirjam M, Attardi Laura D, Jacks Tyler, van Steeg Harry, Jonkers Jos, de Vries Annemieke
Abstract excerpt
p53 alterations in human tumors often involve missense mutations that may confer dominant-negative or gain-of-function properties. Dominant-negative effects result in inactivation of wild-type p53 protein in heterozygous mutant cells and as such in a p53 null phenotype. Gain-of-function effects can directly promote tumor development or metastasis through antiapoptotic mechanisms or transcriptional activation of...
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