Article
Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells.
Neoplasia (New York, N.Y.) - 1 May 2008
Junk Damian J, Vrba Lukas, Watts George S, Oshiro Marc M, Martinez Jesse D, Futscher Bernard W
Abstract excerpt
Aberrations of p53 occur in most, if not all, human cancers. In breast cancer, p53 mutation is the most common genetic defect related to a single gene. Immortalized human mammary epithelial cells resemble the earliest forms of aberrant breast tissue growth but do not express many malignancy-associated phenotypes. We created a model of human mammary epithelial tumorigenesis by infecting hTERT-HME1 immortalized...
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