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Article

Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer.

Oncogene - 2 Mar 1995

Thompson T C, Park S H, Timme T L, Ren C, Eastham J A, Donehower L A, Bradley A, Kadmon D, Yang G

Abstract excerpt

To study the interactions between dominantly acting oncogenes and tumor suppressor genes we used p53 'knockout' mouse urogenital sinus tissue for retroviral transduction of ras and myc in the mouse prostate reconstitution (MPR) model system. Epithelial hyperplasia was observed in all wild-type p53 MPRs with one small focal cancer and no evidence of metastasis. Prostatic cancer was found in 100% of the...

Topics

Alleles
Animals
Base Sequence
Cell Line
Genes, myc
Genes, p53
Genes, ras
Male
Mice
Molecular Sequence Data
Neoplasm Metastasis
Prostatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA

Source

Identifiers

PMID: 7534899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7534899-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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