Article
High metastatic potential in mice inheriting a targeted p53 missense mutation.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2000
Liu G, McDonnell T J, Montes de Oca Luna R, Kapoor M, Mims B, El-Naggar A K, Lozano G
Abstract excerpt
To understand the relevance of p53 missense mutations in vivo, we generated a mouse containing an arg-to-his substitution at p53 amino acid 172, which corresponds to the R175H hot-spot mutation in human tumors by homologous recombination. Inadvertently, this mouse contains the additional deletion of a G nucleotide at a splice junction that attenuates levels of mutant p53 to near wild-type levels. Mice...
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