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Article

p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner.

Cancer research - 1 Dec 2010

Addadi Yoseph, Moskovits Neta, Granot Dorit, Lozano Guillermina, Carmi Yaron, Apte Ron N, Neeman Michal, Oren Moshe

Abstract excerpt

The p53 tumor suppressor exerts a variety of cell-autonomous effects that are aimed to thwart tumor development. In addition, however, there is growing evidence for cell nonautonomous tumor suppressor effects of p53. In the present study, we investigated the impact of stromal p53 on tumor growth. Specifically, we found that ablation of p53 in fibroblasts enabled them to promote more efficiently the growth of...

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Identifiers

PMID: 20952507
DOI: 10.1158/0008-5472.CAN-10-1146
PMCID: PMC2999653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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